Homeostastic Model Assessment and Insulin Sensitivity/Resistance

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Homeostastic model assessment and insulin sensitivity/resistance.

Homeostasis is the manifestation of a large network of integrated metabolic reactions and signaling pathways designed to maintain life and function in a stable manner. Insulin is an integral part of this regulatory network and affects virtually all its parts. The actions of insulin vary in time (1) as well as in the various tissues it affects as demonstrated, for example, by selective receptor ...

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15 صفحه اول

Minimal model-based insulin sensitivity has greater heritability and a different genetic basis than homeostasis model assessment or fasting insulin.

Insulin resistance is an important risk factor for development of type 2 diabetes as well as other chronic conditions, including hypertension, cardiovascular disease, and colon cancer. To find genes for insulin resistance it is necessary to assess insulin action in large populations. We have previously measured insulin action in a large cohort of subjects (Insulin Resistance and Atherosclerosis...

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ژورنال

عنوان ژورنال: Diabetes

سال: 2014

ISSN: 0012-1797,1939-327X

DOI: 10.2337/db14-0116